Abstract

SYNTHESIS, CHARACTRIZATION AND ANTIMICROBIAL ACTIVITY OF 3,5-DIARYL-4,5-DIHYDRO-2-ISOXAZOLINE DERIVATIVES: STRUCTURE-ACTIVITY AND RELATIONSHIP

Ravi R. Vidule and Madhav M. Kendre*

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Abstract

Isoxazoline is the five member heterocyclic compound containing nitrogen and oxygen are found to be new sources for the synthesis of biologically active derivatives. Isoxazolines are the azole in which an oxygen atom is present next to nitrogen. These are found in a large number of natural products and in biologically active molecules. The derivatives of isoxazolineconstitutes different classes of heterocycles having diverse applications, including agrochemicals as fungicides, insecticides, drugs, dyes, rubber chemicals, flavoring agents and in materials science. These isoxazolines represent an important heterocyclic system commonly found in natural products and bioactive compounds. A novel series of 3,5-diaryl-4,5-dihydro-2-isoxazolines (2a-d) from (E)-1-(2-hydroxy-3,5-substituted-phenyl)-3-(2/4-ethoxy-phenyl)-prop-2-en-1- one (1a-d) in ethanol by the addition of hydroxylamine hydrochloride and sodium acetate in the acidic medium by refluxing in oil-bath. The synthesized derivatives were characterized by FT-IR, 1H NMR, 13C NMR, LCMS and elemental analysis. All these synthesized derivatives screened for antibacterial and antifungal activities and are showing potent antimicrobial activities.

Keywords: Chalcones, Isoxazoline, hydroxylamine hydrochloride, sodium acetate, Antimicrobial activities.