Abstract

SIMPLE AND EFFICIENT SYNTHESIS OF BIS-(4- HYDROXYCOUMARIN-3-YL)METHANE DERIVATIVES USING LGLUTAMIC ACID AS CATALYST

Bhaskar P. Ankush and Nana V. Shitole*

Abstract

In the present study, we reports synthesis of bis-(4-hydroxycoumarin- 3-yl)methaneby the one-pot-multicomponent reaction of different substituted aromatic aldehyde/heterocyclic aldehydes and 4- hydroxycoumarine in the presence of L-Glutamic acid (5mol %) as a catalyst in water : ethanol (1:1). The reaction mixture was stirred at reflux temperature for specified period of time. We found that this is a facile and efficient method for the synthesis of bis-(4- hydroxycoumarin-3-yl)methane. The prominent features of this method are the inexpensive reagents, simple and safe experimental procedure, easy and clean workup, short reaction times (05-40 min), excellent yield (52-99 %), no toxic waste and environmentally benign method.

Keywords: 4-Hydroxycoumarine, bis(4-hydroxy coumarin-3-yl)methane, L-Glutamic acid.