Abstract

VOLUMETRIC AND ULTRAACOUSTIC APPROACH TO INTERACTION OF SODIUM SALICYLATE AND 4- AMINOANTIPYRINE DRUGS IN AQUEOUS GLYCINE/L-PROLINE SOLUTION AT DIFFERENT TEMPERATURES

R. T. Sawale*, S. S. Tiwade, D. B. Kadam and A. D. Arsule

Abstract

Major drugs are small organic molecules with the purpose to inhibit and activate the function of biomolecules such as lipids, carbohydrates and proteins. Drug design and development process involves the design of molecules to facilitate the drug mechanism and their action. Studies of thermophysical and biological properties play a vital role to understand the pattern of molecular interactions of drug with the biomolecules. Present article, reports the density, ultrasonic velocity and refractive index of sodium salicylate and 4-aminoantipyrine in aqueous solution of glycine/L-proline at T = (303.15, 308.15 and 313.15) K and atmospheric pressure. Apparent molar properties such as apparent molar volume ( 2, V ) and apparent molar compressibility (   S,2, ) have been calculated from , u and n data. The standard partial molar volumes ( o V 2, ) and compressibilities ( 0 ,2,  S ) of solute in aqueous glycine/L-proline solution have also been obtained by extrapolating the plots. These properties have been interpreted in terms of hydration behaviour and solute-solute/solute-solvent interactions of sodium salicylate and 4- aminoantipyrine drugs in studied solution.

Keywords: Molecular interaction, NSAID, Amino acid, Aqueous solution, Thermodynamic properties.