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Abstract

STERIOCHEMICAL ASSIGNMENT OF ALCOHOLS –A VERSATILE CHIRAL BUILDING BLOCKS STUDIES TOWARDS TOTAL SYNTHESIS OF (-)-AUREONETOL

Govind Jadhav, Prasad Kadam, Ganpat Nagargoje, Abhay Bondge, Shital Jadhav,

Vijaykumar More

Abstract

A novel and interesting synthetic strategies. However, there is enough scope to develop a more efficient synthetic approach for the synthesis of (-) -Aureonetol. Wittig olefination of the aldehydes or ketones to get allyl vinyl ethers followed by a Claisen rearrangement for the generation of 4-pentenal. This method has been extensively studied and applied to the synthesis of (-) –Aureonetol.

Keywords: Dicyclohexylidene protection, Oxidative cleavage, Wittig reaction and Claisen rearrangement.


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