Abstract

A REVIEW ON VARIOUS ASPECTS OF THE PULSATILE DRUG DELIVERY SYSTEM AND RECENT TECHNOLOGIES

Akshay Pashte*, Prashant Shamkuwar, Akash Kale and Aditi Baware

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Abstract

Pulsatile drug delivery systems have great interest these days because they deliver the right amount of drug to the right place at the right time. This provides many benefits over traditional dosage forms and improves patient compliance. Drug administration in chronopharmaceutical therapy is coordinated with circadian rhythms to achieve full therapeutic efficacy and increase patient safety. This drug delivery system is designed to deliver drugs in time with your body clock. The impulse should be designed so that full and rapid release is achieved after the lag time. These systems are advantageous for APIs with chrono-pharmacological behavior that require nocturnal dosing and drugs with high first-pass effect and specific sites of absorption in the GIT. A pulsatile drug delivery system is essentially a time-limited drug delivery system in which the lag time is modulated independently of environmental factors such as pH, enzymes, and gastrointestinal motility. The rationale for using pulsed release is for drugs where the continuous release of the drug is not required, i.e., zero-order release. The purpose of this review is to introduce the concept of chronopharmaceuticals and cover the technology. They are designed to achieve pulsatile delivery, such as OROS Technology, TIMERX Technology, DIFFUCAPS® Technology, CODOS Technology, etc.

Keywords: Time release, Chronotherapeutic, Circadian rhythm, Pulsincap.