Abstract

RECENT ADVANCEMENT IN ORALLY DISINTEGRATING TABLETS

Sneha Vasant Taksal*, Atul S. Pratapwar and Mohammad Zishan Ibrahim

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Abstract

The review sheds light on the advancements in development and characterization of orally dispersible tablet formulation to present an impact on drug material characteristics to improve it's bioavailability. The purpose of the article is to overview potential advancements of orally dispersible tablet (ODT) technology in drug delivery system. Various techniques are use to formulate the orally dispersible tablets (ODTs) include freeze drying, spray drying, direct compression method, sublimation, tablet moulding, and mass extrusion. ODTs could be preferred choice especially with those drugs sensitive to gastro intestinal contents and for patients under category of paediatrics, geriatrics, bedridden, postoperative and who may have difficulty to swallow the conventional tablets and capsules. Orally disintegrating tablet (ODTs) are single unit solid dosage form that involves the rapid disintegration and dissolution of dosage form presenting as solution or suspension state when placed in the mouth. ODTs render enhanced acceptability due to its patient compliance as well as improved bioavailability and stability. This article overview recent trends undertaken to develop ODTs.

Keywords: Orodispersible tablet, Solid orals, ODT technology.