Abstract

ADVANCEMENT IN PELLETIZATION TECHNOLOGY: A SYSTEMATIC REVIEW

Sanika Narendra Mate*, Ravikiran B. Wakade and Pranav A. Revaskar

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Abstract

Pelletization can be defined as an agglomeration process that converts fine powders or particles of a bulk drug and excipients into small, freeflowing, more or less spherical units, called pellets. The size of the pellets is 0.5-2mm. Pellets have the free flowing capacity and have low porosity about 10%. Preparation methods include direct pelletizing powder layering, Suspension or Solution layering, pelletization by extrusion and spheronization, spherical agglomeration, compression/balling, Cryo pelletization, melt spheronization, globulation or droplet formation, fluid bed coating. Pellets have various advantages when compare to normal conventional dosage forms, like they help in giving accurate dosage to the paediatrics and geriatrics and even to the bed ridden persons, reduces peak plasma fluctuation, Minimize potential side effects without lowering bioavailability, avoiding high local concentration, Less susceptible dose dumping.

Keywords: Pellets, Bioavailability, modified multiple dosage form, improved patient compliance.