Abstract

FORMULATION DEVELOPMENT AND EVALUTION OF CARBAMAZEPINE NANOPARTICLES FOR INTRANASAL DELIVERY

Sonawane Jyoti*, Pawar Pravin, Throat Rohini, Sakshi Jadhav and Sawant Pritam

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Abstract

Many drugs are effective at their site of action but in case of central nervous system (CNS) delivery they are discarded during their development for clinical use due to a failure to deliver them in sufficient quantity to the CNS. As a consequence, many diseases of the CNS are undertreated. However, if drug substances can be transferred along the olfactory nerve cells through nose they can by pass the BBB and enter the brain directly. Dispersion of drug in preformed polymers is a common technique used to prepare biodegradable nanoparticles from poly (lactic acid) (PLA), poly (D, L-glycoside) (PLG), poly (D, L-lactase-co-glycoside) (PLGA) and poly (cyanoacrylate) (PCA). Solvent evaporation was the first method developed to prepare PNPs from a. In this method, polymer solutions are prepared in volatile solvents and emulsions are formulated. The encapsulating polymer is dissolved in a partially water soluble solvent such as propylene carbonate and saturated with water to ensure the initial thermodynamic equilibrium of both liquids. Salting out is based on the separation of a water miscible solvent from aqueous solution via a salting out effect. The salting out procedure can be considered as a modification of the emulsification/solvent diffusion. Dialysis offers a simple and effective method for the preparation of small, narrow-distributed PN.

Keywords: Carbamazepine, Nasal delivery.