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Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES OF ANTI MICROBIAL AGENTS OF BCS CLASS II & IV DRUGS

*Vivek Upadhyay and Kamal Singh Bani

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Abstract

Since we know that medication should be bioavailable to achieve therapeutic effect in the human body and hence it depends on drug solubility. The solvent dissolution process is one of the essential requirements for achieving the desired concentration of the drug in the systemic circulation for the desired pharmacological response. Low aqueous solubility is the main problem experience with the production of formulation of new chemical entities as well as with the generic progression. Throughout More than 40 percent of the NCEs (new chemical entities) in the pharmaceutical industry are virtually insoluble in water. Solubility is a huge obstacle for researchers. working on formulations. The pharmaceutical production of drugs with low water solubility requires that a compatible formulation layout be formed between different techniques. Various mechanisms for enhancing the aqueous solubility and low dissolution rate of BCS class II and IV drugs have been studied extensively. The Biopharmaceutical Classification Scheme represents the low water solubility, slow degradation, and low bioavailability of Class II and IV products. This review article discusses the different strategies for enhancing the solubility of hydrophobic products, such as drug complexation, cosolvent use, emulsion creation, Pharmaceutical salts, prodrug technology, particle size reduction technology, solid state alternation technology, soft gel technology, solid dispersion techniques, nanocrystals, nanomorphic technology, and crystal techniques. Microemulsions, micelles, ceramic micelles.

Keywords: NCE, Dissolution, Solubility, Techniques, BCS.


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