Abstract

FORMULATION DEVELOPMENT AND CHARACTERIZATION OF SUPERPOROUS HYDROGEL OF ITOPRIDE HYDROCHLORIDE FOR GASTRORETENTIVE DRUG DELIVERY SYSTEM

Santosh R. Tambe, Leena P. Deore* and Devidas G.Bachhav

Abstract

Aim of this research was development and characterization of Itopride hydrochloride superporous hydrogel to extend drug release. Synthesis of superporous hydrogel composites was carried out by solution polymerization using sodium bicarbonate as gas blowing agent. 50% acrylamide solution (AM) and 50% acrylic acid solution (AA) as a monomer, 2.5% N,N’-methylene bisacrylamide (BIS) as a cross linker, 20% Ammonium persulphate (APS) and 20% N,N,N’,N’- Tetramethylethylene diamine (TEMED) as a polymerization initiator pair, 10% Pluronic F127 solution as a foam stabilizer used for synthesis of superporous hydrogel composites. Its characterization performed by density, water retention capacity, in-vitro buoyancy study, floating time, swelling ratio, swelling time, porosity, scanning electron microscopy, in-vitro drug release and stability. The drug release profiles were fitted to various kinetic models to determine drug release pattern. Density was found to be less than gastric content, swell within time limit, also show degradation kinetics, float within few seconds and floating time more than 12 h. FTIR studies shows all prominent peaks of drug in formulation F-8 and DSC indicate cross linking. The drug release profiles was fitted to korsmeyer-peppas model (R2=0.9967) and n values were found within limit 0.3724 ( e.g. Less than 0.45) suggesting probable release by fickian diffusion (Higuchi matrix). Also stability study for formulation F-8 carried out at 40 ºC and 75% RH for one month, formulation found to be stable. The prepared systems can be effective for extending drug release reducing the dosing frequency and may improve the bioavailability of Itopride hydrochloride.

Keywords: Superporous hydrogel, Gastrotetentive drug delivery, Gas blowing technique.