Abstract

AN EFFICIENT IMPROVED SYNTHESIS OF NPHENYLCINNAMAMIDE ANALOGOUS PROMOTED BY CDI / ET3N.

D. Ramakrishna, B. Priyanka and Dr. N. Krishna Rao*

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Abstract

The synthetic pathways protocol followed by antimicrobial study of Nphenylcinnamamide (4).These derivatives can be synthesized from cinnamoylchloride (2) with substituted aromatic anilines (3)in the presence of dehydro halogenating reagent such as triethyl amine and CDI in methylene dichloride at reflux. The compound (2) also can be prepared from cinnamic acid and thionylchloride in the presence of MDC at 5-100C. All the derivatives evaluated by advanced spectral data (1HNMR, 13CNMR & LCMS) and the structure of the all titled compounds can be determined by elemental analysis. In addition to evaluation of ant-microbial activities against four bacterial strains as well as two fungal strains.

Keywords: Cinnamoylglycine substituted aromatic amines, CDI, N-phenylcinnamamide. Antimicrobial activity.