Abstract

ACUTE TOXICITY STUDY AND ANALGESIC ACTIVITY OF SIDDHA POLY HERBAL DRUG AVURI KARPAM

Dr. T. Giftillda Selva Elsee*, Dr. E. M. Manikgantan and Dr. G. Bharath Kumar

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Abstract

Avuri Karpam (AK) is a poly herbal formulation mentioned in Classical Siddha literature Pathartha Guna Vilakkam and it contains Avuri ilai (Indigofera tincotria), Kaiyanthagarai (Eclipta alba), Kuppaimeni (Acalypha indica), Kottaikkaranthai (Spaeranthus indicus), Vallarai (Centella asiatica), Pottrilai kaiyanthagarai (Wedelia chinensis), Seruppadai (Coldenia procumbens) indicated for treating Keelvatham (Arthritis), Udhirakkattu, Sarpavisham. Safety and efficacy of the drug AK has not been evaluated scientifically. The aim of the present study was carried out the acute toxicity study accordance with OECD guidelines and analgesic pharmacological activity in rats. Acute toxicity study had been carried out at the dose level of 5 mg/kg and 2000mg/kg. At these two doses level does not reveal any abnormalities. No mortality was documented. Whereas analgesic activity study, Group- I is normal control (0.5% CMC p.o.), and Group- II received Pentazocine (30mg/kg, i.p.), whereas Groups - III and IV animals received AK (400 and 800 mg/kg, p. o respectively). Latency period of AK low dose and high dose significantly given significant results when compared to standard drug at the time interval of 30 mins, 45 mins, and 60 mins. Since it was concluded that Siddha drug AK is non-toxic and it has potent analgesic activity.

Keywords: Siddha medicine, Herbal drug, Avuri Karpam, Acute toxicity, Analgesics.