Abstract

AN EFFICIENT SYNTHESIS, CHARACTERIZATION AND BIOEVLUATION OF SCHIFF’S BASE CONTAINING BENZIMIDAZOLES MOIETY CATALYZED BY TFA

T. Jagadeesh, M. Divya, B. Pryanka and N. Krishnarao*

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Abstract

Schiff’s bases possessing a significant class of medicinally and pharmaceutical important moieties. An efficient process for the synthesis for a novel Schiff bases from 5-styryl-1, 3, 4-thiadiazol-2- amine with P-substituted aromatic aldehyde by using Trifluoroaceticacid in ethanol as solvent at reflux. The intermediate moiety 5-styryl-1, 3, 4-thiadiazol-2-amine can be synthesized from cinnamic acid with semithiocarbazide in the presence of ethanol with concentrated sulphuric acid medium. All the newly synthesized compounds were evaluated by the advanced spectroscopic data (1HNMR, 13CNMR and LCMS) and also structural determination titled compounds were calculated by elemental analysis. Subsequently all newly compounds were studied by their anti-microbial activity.

Keywords: Cinnamic acid, semithiocarbazide, 5-styryl-1, 3, 4-thiadiazol-2-amine, Psubstituted aromatic aldehydes, schiff bases, bioevluation.