Abstract

AN EFFICIENT BIO ACTIVE SYNTHESIS OF N-SUBSTITUTED ACRIDINE ANALOGOUS

Ch. Jyothi, B. Pryanka and N. Krishna Rao*

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Abstract

An efficient synthesis of N-alkyl analogous of acridine 10-benzyl-9- (4-Chlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine- 1,8(2H,5H)-dioneis by obtainedfrom9-(4-Chloropnenylhenyl)-3,3,6,6- tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8 (2H,5H)-dione with substituted (bromomethyl)benzene which is also three component cyclocondensation of 1,2-dicarbonyl compounds like dimedone, chloro benzaldehyde and ammonium chloride in the presence KIO4 solvent free condition. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR & LCMS) and the structural determination of the novel derivations was calculated by elemental analysis. In the present study, ten hybridized acridine derivatives were synthesized via cyclo condensation and evaluated for their invitro antimicrobial activity.

Keywords: Dimedone, Chlorobenzalehyde, KIO4, 10-benzyl-9-(4-Chlorophenyl)- 3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1, 8(2H,5H)-dione, 9-(4-Chlorohenyl)- 3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1, 8(2H, 5H)-dione, Anti-microbial activites.