DEVELOPMENT AND EVALUATION OF FAST DISINTEGRANT TABLETS (FDTs) OF TERBUTALINE SULPHATE
Neeraj Rajput*, Munish Garg Monga, Chhote Lal Singh, Amit Singh and Sokindra Kumar
Abstract
The purpose of this study was to evaluate the effect of
superdisintegrants on the mouth dissolving property of fast
disintegrants tablets (FDTs) of terbutaline sulphate. Fast dissolving
tablets of terbutaline sulphate were prepared by direct compression
method; using superdisintegrants sodium starch glycolate (F1-F3) and
sodium carboxy methyl cellulose (F4-F6), designated as six different
types of formulation at different concentration of 6%, 12%, 18%
respectively and keeping constant concentration of drug and excipients
were used to formulate fast disintegrants tablets. Formulations were
evaluated for Precompression parameters such as bulk density, tapped
density, angle of repose, Carr‟s index and Hausner‟s ratio. Post compressed parameters like
thickness, hardness, friability, wetting time, weight variation, drug content uniformity, invitro
disintegration time and in-vitro dissolution studies of compressed tablets. Drugsuperdisintegrants
interaction studies were characterized by FTIR spectroscopy. The values
of Pre-compression parameters evaluated were within prescribed limits and indicated good
free flowing property. All the post compression parameters evaluated were found within IP
acceptable limits. No chemical interaction between drug and superdisintegrants confirmed by
FTIR. Thickness of tablets was found in the acceptable range of 2.20 mm. Hardness and
friability of tablets was found to be 2.5-4.2 Kg/cm2 and 0.13-0.26% respectively. The in vitro
disintegration time were found to be 14-38 sec. result fulfil the official requirements. The
drug content uniformity and wetting time was found in between 91-97% and 35-78 sec
respectively, results were within IP acceptable limits. The in vitro dissolution release of drug
was found to be in acceptable range of 73-98%.
Keywords: Fast disintegrants tablets, Superdisintegrants, Terbutaline sulphate, Direct compression method, FTIR.
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