Abstract

THERAPEUTIC PHYTOCONSTITUENTS FOR ALZHEIMER’S DISEASE: AN OVERVIEW

Rao Monica R. P.*, Valvi Abhijeet, Misal Poonam, Gaikwad Pranjali, Narale Vaibhav and Karmankar Darshan

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavioural changes. This review explores the potential of phytoconstituents derived from medicinal plants as alternative treatments for AD. It provides an overview of currently approved medications and disease-modifying immunotherapies but highlights the need for improved therapeutic options due to limitations and side effects. The review focuses on key phytoconstituents, including baicalein, quercetin, and berberine, discussing their pharmacological properties in mitigating oxidative stress, reducing inflammation, promoting neuronal health, and inhibiting protein aggregation. However, challenges related to bioavailability and metabolisms hinder their efficacy. The use of targeted nanocarrier systems shows promise in enhancing their delivery and bioactivity. By combining. traditional knowledge with modern advancements, this review emphasizes the therapeutic potential of phytoconstituents in AD management. Further research, including rigorous preclinical and clinical trials, is crucial to validate their effectiveness, optimize delivery strategies, and advance neurodegenerative disease treatment. In conclusion, investigating phytoconstituents as complementary treatments to conventional AD medications offers new possibilities in the battle against Alzheimer's disease.

Keywords: Alzheimer’s, Phytochemicals, Alternative therapy, Neurodegenerative.