Abstract

ANTIBACTERIAL EFFECT COMPARISON OF JATROPHA CURCAS LINN. LEAVES AND CINNAMOMI BURMANII CORTEX EXTRACT TOWARDS STAPHYLOCOCCUS EPIDERMIDIS

Sri Agung Fitri Kusuma*, Danni Ramdhani and Ana Indrayati

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Abstract

Objective: This study was aimed to compare the antibacterial effect of Jatropha curcas leaves and Cinnamomi burmanii cortex extract against Staphylococcus epidermidis. Methods: Jatropha curcas leaves and C. burmanii cortex were macerated in the 70% ethanol as the solvent. Then both extract's secondary metabolites were analyzed using a standard method. The antibacterial activity of both samples extract was evaluated on the growth of S. epidermidis in vitro using the agar diffusion method at various extract concentrations of 20, 40, 60, and 80 %w/v. Minimum inhibitory concentration (MIC) values of the extracts were determined using the broth dilution method at a dilution concentration of 0.3125. 0.625; 1.25; 2.5; 5.0 and 10% w/v. Results: C. burmanii cortex demonstrated stronger antibacterial activity against S. epidermidis in the MIC/MBC values of range 0. 3125 to 0.625%w/v than that of J. curcas extract with the MIC/MBC ranging from 0.625 to 1.25 %w/v. Conclusion: C. burmanii cortex can be furthered to be developed as a potential antiinfectious natural drug against S. epidermidis.

Keywords: Cinnamomi burmanii, cortex, Jatropha curcas, leaves, Staphylococcus epidermidis.