Abstract

NANOCARRIER BASED DRUG DELIVERY SYSTEMS FOR LYMPHATIC TARGETING

Munikoti Lakshmi Kavya*, Abbas Ali, Brahmaiah Bonthagarala, M. Mohan Varma and K. S. Nataraj

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Abstract

The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, The lymphatics transport material from peripheral tissues to lymph nodes, where immune responses are formed, before being transported into systemic circulation, with key roles in transport and fluid homeostasis, lymphatic dysregulation is linked to diseases, including lymphedemas. There is a system which is responsible for the specific resistance and in some aspects; nonspecific resistance is the lymphatic system which maintains homeostatic balance. This system closely allied with all the systems. Lymphatic system cons fluid called, lymph. It assists in circulating body fluids and helps in defend the body against disease causing agents. B cells, T cells and antibodies protect all body systems from attack by harmful foreign invaders (pathogens), foreign cells, and cancer cells. Major functions of lymphatic system are draining excess interstitial fluid, transport dietary lipids and carrying out immune responses. Now a days there is a high risk to immune system because of the diseases or due to disorders. In recent innovations, nano technology plays a major role and there are the different drug carriers are used to avoid the major damage to immune system. This review explains about the drug carriers to target lymphatic system to release the drug at a specific part in the lymphatic organs, tissue or lymph in different disease conditions. Future perspectives and conclusions concerned with lymph-node-targeted drug-delivery systems are also provided.

Keywords: lymphatic system, Nano drug carriers, drug targeting, drug release mechanism, barrier.