EVALUATION OF CYTOTOXIC AND EX-VIVO CARDIOPROTECTIVE INVESTIGATION OF ETHANOLIC EXTRACT OF GLYCOSMIS PENTAPHYLLA LEAVES
Prawej Ansari, Shofiul Azam, Md. Reyad-ul-ferdous1*, Jalish Mahmud, Md. Monirul Islam, Sukdeb Goswami1 and Md. Naimul Islam
Abstract
The present study was designed to investigate the cytotoxic activity of
methanol extract of Glycosmis pentaphylla on brine shrimp and
thrombolytic activity of methanol extract of Glycosmis pentaphylla on
human blood. Ethanolic extract of G. pentaphylla was assessed with
the Brine shrimp lethality bioassay was used to evaluate cytotoxicity
and ethanolic extract of G. pentaphylla assessed with human blood to
evaluate thrombolytic effect. The extract showed remarkable cytotoxic
activity, LC50 value of the extract was 2.8315μg/ml compared to
vincristin sulphate, a reference drug. It also has evaluated as
thrombolytic agent compared to streptokinase. It has significant thrombolytic effect
which was about 33.144%. These findings demonstrate that the leaves extract of G.
pentaphylla have excellent cytotoxic activity and Glycosmis pentaphylla have excellent
thrombolytic effect.
Keywords: Glycosmis pentaphylla, bioassay, cytotoxic, LC50, cardioprotective activity.
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