Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL OF SOME NOVEL THIADIAZOLES DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

B. Janaki*, A. Aswani and G. Hema

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Abstract

Thiadiazoles and their analogues exhibit a wide variety of biological activities like antibacterial, antifungal, antitubercular, antidiabetic, anti-inflammatory, anti-convulsant, diuretic etc., In the present research work, Thiadiazoles derivatives were synthesized from various aryl carboxylic acids with thiosemicarbazide to form various 2-amino- 5-aryl-1,3,4-thiadiazole analogues. The purity of the compounds was identified by TLC and are purified by recrystallization and column chromatography. The structures were determined by IR, 1H NMR and Mass spectral data. The diversified 2-amino-5-aryl-1,3,4-thiadiazoles were screened for their antibacterial (Gram positive Staphylococcus aureus (ATCC 9144), Gram negative Escherichia coli (ATCC 25922), and Aspergillus niger (ATCC 9029) by cup plate diffusion technique. Based on the results of the antitubercular activity SAR of the synthesized compounds is drawn.

Keywords: Thiadiazole, antibacterial, antifungal, antitubercular.