Abstract

REVIEW ON POLYHERBAL NANOSUSPENSION AND APPROACHES TO ENHANCE SOLUBILITY OF DRUGS

Neha Quadri* and Dr. Mohd. Mustaqeem Abdullah

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Abstract

The focus of this Review is on drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems, such as nanoparticles, have been used as a physical approach to change and improve the pharmacokinetic and pharmacodynamic properties of various drug molecules. One of the most serious issues with poorly soluble herbs is their low bioavailability. The situation is even more complicated for herbs such as garlic, psyllium, and chamomile, which are poorly soluble in both aqueous and nonaqueous media and are classified as BCS class II by the biopharmaceutical classification system. Formulation as a nanosuspension is an appealing and promising solution to these problems. They have been used in vivo to protect the drug entity in systemic circulation, limit drug access to the selected sites, and deliver the drug at a controlled and sustained rate to the site of action. Nanosuspensions are made up of a poorly water-soluble drug suspended in a dispersion of matrix material. The preparation of nanosuspension is simple and applicable to all drugs that are insoluble in water. A nanosuspension not only solves the problem of poor solubility and bioavailability, but it also changes the pharmacokinetics of the drug, improving its safety and efficacy. The treatment involves the use of a single herb or a combination of herbs (polyherbalIndividual plant active phytochemical constituents are insufficient to achieve the desired therapeutic effects. When multiple herbs are combined in a specific ratio, the therapeutic effect is enhanced while toxicity is reduced. This review focuses on the importance of polyherbalism, preparation methods, characterization, and nanosuspension applications.

Keywords: Poly Herbal, Drug Delivery, Nano-suspension and Bioavailability.