Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM

Pranita Suresh Kumbhar*, Aditi Shashikant Thakur, Preeti Rajendra Zadake and Sakshi Krushna Kamble

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Abstract

The human skin is a readily accessible surface for drug delivery. Adult body covers a surface of skin is approximately 2m2 and receives about one-third of blood circulating through the body. The human skin surface contain on an average, 10-70 hair follicles and 200-250 sweat ducts on every square centimeter of skin area. Transdermal drug delivery system also known as “patches”. A transdermal patch is a medicated adhesive patch that is place on skin to delivery drug through the skin and into the blood stream. The conventional oral dosage forms has significant drawbacks of poor bioavailability due to hepatic first pass metabolism and tendency to produce major fraction of drug is transported into the systemic blood circulation, leading to a need for high or frequent dosing, which can be both cost prohibitive and inconvenient. To improve such characters transdermal drug delivery system was emerged which will improve the therapeutic efficacy and safety of drugs by more precise placement within the body thereby reducing both the size and number of doses. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such activity of transdermal drug delivery system was emerged. Excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This review article covers brief merits, demerits, physiology of skin, route of penetration, factors affecting, basic components, recent technique for TDDS, evaluation.

Keywords: Polymer matrix, Drug, Penetration enhancers, Topical drug delivery, Systemic blood circulation.