Abstract

A REVIEW ON BUCCAL FILMS: AN ALTERNATIVE APPROACH IN DRUG DELIVERY SYSTEM

Abushan Khan* and Dr. Sobhna Singh

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Abstract

Local and systemic drug delivery can be facilitated through buccal drug delivery, which involves the administration of medications to the buccal mucosa[1], which is located inward of the cheek inside the mouth. The review was based on the different aspects of buccal filmsits formulations, polymers used and evaluation parameters. The literature was extensively searched through various scientific and reputed platforms i.e., Scopus, PubMed, Google scholar etc. Salivary mucus is a protective covering on epithelial surfaces that is secreted by salivary glands. There are several different substances that make up this barrier, i.e., water etc. Mucoadhesion is the basic mechanism of its action that utilized various pathways i.e., wetting, diffusion, adsorption and fracture. It uses diver polymers i.e., hydroxypropyl cellulose, hydroxyethyl cellulose, chitosan, gelatin, Xyloglucan etc. as mucoadhesive agent. Mucoadhesive films are formulated through these techniques such as solvent casting, hot melt extrusion, inkjet printing and 3D printing. Mucoadhesive films are evaluated by different parameters including dissolution, mucoadhesive strength, residence time and in-vitro permeation studies. It concludes that mucoadhesive film is the chosen dosage forms with rapid onset on action, better bioavailability, patient compliance with minimized dose level due to avoidance of hepatic metabolism.

Keywords: Buccal films, chitosan, solvent casting, mucoadhesion and bioavailability.