Abstract

NOVEL APPROACHES FOR INSULIN DELIVERY FOR TREATMENT OF DIABETIC PATIENTS: A REVIEW

Deepali Rana* and Dr. Nita Sharma Das

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Abstract

Diabetes Mellitus is a serious condition caused by insufficient insulin secretion and is the cause of serious health problems worldwide. In the early 19th century, diabetes was thought to be a pancreatic- related insufficiency of the digestive system and was hypothesized to be related to regulation of carbohydrate metabolism. Many diabetic patients rely on subcutaneous insulin injections. The burden of insulin injections for many patients that encouraged research for new delivery methods, and a variety of non-invasive and invasive delivery of insulin are now available. This review describes a variety of new drug delivery systems including buccal, oral, rectal, vaginal, intraperitoneal, transdermal, inhalation, colonic insulin delivery, various types of insulin pumps, and pens. Many techniques have been investigated to make non-invasive insulin administration feasible. This review article focuses on past, present and future aspects of insulin delivery methods, their advantages and limitations, and potential opportunities for new insulin drug development.

Keywords: Diabetes, New delivery methods, inhaled insulin delivery, oral insulin delivery, insulin pens and pumps.