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Abstract

DESIGN AND IN-SILICO STUDIES OF NOVEL QUINOLONE BASED DERIVATIVES AS ANTI-BACTERIAL AGENTS

Preety*, Karishma Singhal and Devendra

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Abstract

The first examples of quinolone antibiotics, which had a limited span of action and antagonistic pharmacokinetic characteristics, appeared in the early 1960s. A family of synthetic broad-spectrum antibiotics known as quinolones. Strong synthetic chemotherapeutic anti-bacterial agents are referred to as quinolones. Nalidixic acid, which has bactericidal activity, serves as the precursor of the first generation of quinolones, which were initially developed in 1962 for the treatment of human urinary tract infections. George Lesher made the discovery of nalidixic acid. Quinolones are antibiotics with a broad spectrum of activity that are effective against mycobacteria, Gram-positive and Gram-positive bacteria, as well as anaerobes. By destroying the enzymes topoisomerase IV and topoisomerase II, DNA gyrase, and breaking bacterial chromosomes, they use their behaviour to prevent bacterial nucleic acid emulsion. Due to excessive usage of these drugs, bacteria have developed resistance to quinolones, which is comparable to resistance to other antibacterial agents. We must therefore create fresh antibacterial for this reason.

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