Abstract

A REVIEW ON FIRST GENERATION OF TRANSDERMAL DRUG DELIVERY SYSTEM

*Jashoda Chaudhary and Vijaya Bhogale

.

Abstract

The transdermal drug delivery system, skin anatomy, and a brief description of the first generation of TDDS: Transdermal patches are all covered in this TDDS review article. Over the past ten years, there has been a lot of interest in the transdermal delivery of medications into the bloodstream through the skin. The use of transdermal drug delivery systems (TDDS) over traditional dose forms or controlled release systems has various benefits. For the delivery of small, lipophilic, low-dose medicines, clinical use of first-generation transdermal delivery devices has steadily increased. Comparing first generation transdermal drug delivery to traditional parenteral or oral routes reveals advantages. They assure controlled absorption and more consistent drug concentrations in the plasma. Bioavailability is improved by avoiding first-pass hepatic metabolism and enzymatic or pH-associated deactivation.

Keywords: transdermal drug delivery system, TDDS, transdermal patches, polymer matrix, permeation enhancers, drug reservoir.