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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR ESTIMATION OF METHYLISOTHIAZOLINONE IN COSMETIC PRODUCTS

Ashish Jibhakate, Bhagyashree Gahane, Anushri Raut, Arpit Kalbande, Anushka Wankhade, Ashish Chaudhari* and Dr. Koshish Gabhane

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Abstract

Cosmetic products commonly contain preservatives to prevent microbial growth and ensure product safety. Methylisothiazolinone (MIT) is a widely used preservative in various personal care products. The accurate and reliable estimation of MIT is essential for quality control and regulatory compliance. This study aimed to develop and validate a UV spectroscopic method for the quantitative determination of MIT in cosmetic products. The UV spectroscopic method was developed based on the absorption characteristics of MIT in a suitable solvent. The method involved the preparation of standard solutions of MIT and the measurement of their absorbance at wavelength 270nm using a UV-visible spectrophotometer. The calibration curve was constructed by plotting the concentration of MIT against the corresponding absorbance values. The method was optimized by evaluating various parameters such as solvent selection, wavelength, and linearity range. The developed UV spectroscopic method was validated according to the International Conference on Harmonization (ICH) guidelines for validation of analytical procedures. The method was found to be specific, as no interference from excipients or other common preservatives was observed. The linearity of the method was established over a concentration range of 20 to 100 μg/mL, with a correlation coefficient (R²) of 0.96. The accuracy and precision of the method were evaluated through recovery studies and intra-day and inter-day variability studies, respectively. The validated UV spectroscopic method was successfully applied for the estimation of MIT in a range of cosmetic products, including facewash and shampoos. The proposed UV spectroscopic method provides a cost-effective, rapid, and reliable alternative for the routine analysis of MIT in cosmetic products. In conclusion, this research presents the development and validation of a UV spectroscopic method for the estimation of MIT in cosmetic products. The method demonstrated good linearity, specificity, accuracy, and precision. It can serve as a valuable tool for routine quality control analysis and regulatory compliance in the cosmetic industry, contributing to the safety and efficacy of cosmetic products.

Keywords: Methylisothiazolinone, UV spectroscopy, Method development, Validation, Preservatives, etc.


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