Abstract

IDENTIFICATION OF LIMONOID ‘MELIANTRIOL’ FROM AZADIRACHTA INDICA

Pasupuleti Sreenivasa Rao*, Sarvepalli Skandha Harshita, Sarvepalli Vijay Kumar, Gundluru Aruna, Ramalinga Viswa Kumar, Shaik Sadak Basha and Mannur Ismail Shaik

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Abstract

World population up to 80 percent, in most nations depends on traditional medicine for their primary health care. In several phytotherapy based medical practices, native medicinal plant/herbal extracts are widely used to treat various disorders and diseases. Its usage is rapidly emerging due to their beneficial effects and moreover assumed with less toxic side effects. Azadirachta indica (Neem) is an important medicinal plant with high medicinal values. It is a member of family Meliaceae, which is in cosmopolitan in distribution. In India, for centuries, its usage is common in ethno traditional medicine and also in all other medical practices. Its vegetative parts like leaves, flowers, fruits, seeds and bark are rich source for various bio-active compounds. Therefore they were termed as natural drug store or store house of phytochemicals. Its chemical and structural composition is pretty complex. Few bioactive compounds are separated, characterized, and reported with substantial biological properties. However, in the current study, we investigated the distribution pattern of Triterpenes like Meliantriol in the vegetative parts of Azadirachta indica (Neem) extracts through LC–MS (Liquid Chromatography and Mass Spectroscopy) spectral analysis. The results reveal the presence of major Triterpeniods like Meliantriol (C30H50O5) for the first time from the vegetative parts of Azadirachta indica collected from Tirumala Hills, Eastern Ghats, India.

Keywords: Flavonoids, Meliantriol Azadirachta indica, Natural products, LC –MS, (C30H50O5).