Abstract

A REVIEW ON: GASTRO-RETENTIVE DRUG DELIVER SYSTEM

Pooja R. Hatwar*, Dr. R. L. Bakal, Monali D. Dere, Ankita A. Dumare and Pooja D. Hage

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Abstract

The pharmaceutical research sector pays close attention to oral gastroretentive dose forms. The importance of gastro-retentive drug delivery systems increased due to these systems' improved patient compliance with medications with higher therapeutic indices (GRDDS). Floating, bio adhesive, swelling, high density, and magnetic systems are the major components of gastro retentive drug delivery systems, which have become popular as modern methods of improving the bioavailability and regulated delivery of medications with an absorption window. These systems not only enable controlled release of the medication for a long time, but also present the drug in an absorbable form at regions of optimal absorption by extending the gastric emptying time of the dosage form. The CR-GRDF offers a gives patients a way to take advantage of all the pharmacokinetic (PK) and pharmacodynamic (PD) benefits of controlled release dose forms for such medications. This comprises postponed gastric emptying devices such as the floating system, dilation and expansion system, muco-adhesive system, high density system, and others. The advantages, drawbacks, and evaluation of GRDDS are briefly discussed in this article along with formulation considerations for GRDDS and factors affecting stomach retention time. The numerous gastroretentive dose forms for extending stomach residence time are briefly discussed in the current review.

Keywords: Gastro-retentive Drug Delivery System, Floating System, Bioadhesive Systen, High-density System, Raft Forming System.