Abstract

AN OVERVIEW ON IN-SITU NASAL GEL FOR DRUG DELIVERY

Pratik Jadhav*, Rushikesh Jadhav, Sheetal Gondkar, Rishikesh Bachhav

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Abstract

Since in-situ gel nasal drug delivery systems have better overall bioavailability via nasal route as compared to the oral route of administration, the review was conducted to discuss in detail about these systems. A unique dosage type for nasal medication delivery is in-situ gel. Low viscosity solution is infused into the nasal cavity, and after some time, when it comes into contact with the nasal mucosa, it turns into gel. Avoiding first pass metabolism, some medications' high permeability in the nasal epithelium, and fast drug absorption across this membrane are the primary benefits of nasal administration. Compared to conventional drug delivery systems, this method has a quick beginning of action, enhanced patient compliance and ease of use, maintained and prolonged activity. Gel formation is influenced by a variety of variables, including temperature variation, pH changes, the presence of ions, UV radiation, polymorphism, solubility, viscosity, and osmolarity. The review's main topics were the architecture and physiology of the nose, benefits and drawbacks, drug transport mechanisms to the nose, therapeutic considerations, method of formulation, assessment of in-situ nasal gel, and use of in-situ nasal gel.

Keywords: In-situ gel, nasal mucosa, Bioavailability, novel dosage form, first pass metabolism.