Abstract

STUDY ON QUINAZOLINONE DERIVATIVE AND THEIR PHARMACOLOGICAL ACTIONS

Professor Satish K. Patil, *Desale Mayur Sanjay and Pratik Patil

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Abstract

The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, antiinflammatory, anti-HIV, anticancer and analgesic activities.in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention activities investigations of quinazoline derivatives. The biological activities of the synthesized quinazoline derivatives also are discussed. The first quinazoline derivative (2-cyano-3,4-dihydro-4-oxoquinazoline) was synthesized in 1869 by the reaction of cyanogens with anthranilic acid.[15] Many years later quinazoline was obtained by decarboxylation of the 2-carboxy derivative (quinazolinone) which can be synthesized more easily by a different method. Active heterocyclic compounds are one of the main topics of interest for the medicinal chemists as they display a number of pharmacological activities. Nitrogen, sulfur, and oxygen containing five- and six-membered heterocyclic compounds have occupied enormous significance in the field of medicinal chemistry. The most important six-membered heterocyclic compounds are quinazoline and quinazolinone derivatives for their biological activities. The current chapter outlined the different methods for synthesis of quinazoline and quinazolinone derivatives that possess broadspectrum of biological activity. Quinazoline and its oxidized analogs, quinazolinones, are privileged motifs due to their frequent occurrence in natural products and bioactive compounds. Therefore, the development of efficient methods for the synthesis of quinazoline derivatives has been a significant research objective in organic and medicinal chemistry. Although conventional syntheses of quinazoline derivatives generally depend on acid/base-mediated condensation reactions, hetero Diels-Alder reactions, aza-Wittig reactions, etc., modern approaches that utilize transition-metal catalysts have also been developed, enabling streamlined construction of quinazoline frameworks. In this chapter, Cu-mediated methods for the construction of quinazolines and related benzodiazines are surveyed. In addition, Cu-mediated modifications of quinazoline and quinoxaline scaffolds are discussed briefly.

Keywords: Quinazolinone Derivative and Their Pharmacological Actions.