Abstract

AN OVERVIEW OF OPHTHALMIC IN-SITU GEL

Ajit Tuwar*, Nilesh Mahajan, Sheetal Gondkar, Rishikesh Bachhav

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Abstract

The field of ophthalmic drug delivery is one of the most challenging and exciting fields for pharmaceutical scientists. Various polymers are used for in situ ophthalmic gels. Hydrogels are commonly used. These polymers increase the viscosity of the solution. The field of ophthalmic drug delivery is one of the most challenging and exciting fields for pharmaceutical scientists. Over the past 10-20 years, this area has improved significantly. Care should be taken when formulating new products due to sensitive areas and many application site limitations. Due to the physiology of the eye, this organ is impervious to foreign substances. Finding a formulation that overcomes the ocular protective barrier in such a way that the drug reaches the site of action in sufficient concentration is difficult. New drug delivery systems aim to overcome biological barriers that may hinder effective drug delivery to the eye. Overcoming protective barriers without damaging permanent tissue presents a significant challenge for formulators. Common diseases that can be treated by local drug delivery include blepharitis, conjunctivitis, keratitis, trachoma, and glaucoma. The main drawbacks of conventional formulations such as solutions, suspensions, emulsions and ointments are their low bioavailability and increased peroneal muscle excretion. Wide variability in efficacy. Due to the convenience and safety of ophthalmic chemotherapy, optical application of the drug is the most preferred formulation.

Keywords: Eye, Ocular Drug Delivery System, Gel, Anatomy.