Abstract

NATURAL BIO - POLYMER:-A REWARD ON CHITOSAN LOADED GAMMA ORYZANOL NANOPARTICLES

Shubham Panday*, Vivek Kumar Patel and Dr. Rajeev Kumar Shukla

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Abstract

The primary goal of this review paper is to present the rapidly expanding field of nanotechnology in medicine, specifically drug delivery. Pharmaceutical sciences use nanoparticles to lessen drug toxicity and adverse effects, but until recently, they were unaware that the carrier systems themselves could put patients at danger. Positively, the potential to breach the blood-brain barrier may create novel avenues for medicine delivery to the brain. The nano-size also permits entry into the cell and other cellular structures, including the nucleus. Due to its abundant supply of nutritionally and economically significant phytochemicals such as oryzanol, lecithin, tocopherols, and tocotrienols, rice bran oil stands out among other edible oils. One such component that has the potential to be employed in medicines, cosmetics, and nutraceutical formulations is γ-oryzanol. It consists of a combination of triterpene alcohols and ferulic esters of sterols. γ-oryzanol is used for its anti-hyperlipidemic activity, antioxidant property, and symptoms of menopause and aging. Some people use it for increasing testosterone and human growth hormone levels, as well as improving strength during resistance exercise training. Chitosan is a natural polymer widely used due to its salient features of biodegradability, biocompatibility, low- toxicity, anti-bacterial, and antimicrobial properties. The mucoadhesive properties of chitosan help in the fabrication of nanoparticles due to its cationic behavior. Chitosan is chosen as a suitable polymer candidate for the fabrication of nanoparticles of γ-oryzanol to protect the molecule from the RES system due to its polycationic nature. Therefore, it helps to increase bioavailability as well as achieve the good anti-hyperlipidemic activity.

Keywords: nanoparticles, ?-oryzanol, chitosan.