Abstract

A COMPENDIUM ON PSORIASIS

Nobitha Binoy*, Fathima P. C., Oliviya Vincent, Shifana V. C., Ameer Suhail T., Aadi Sathyan

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Abstract

Psoriasis is an auto-immune disease characterised by symmetrical, erythematous, scaling papules and plaques in the skin and joints. Psoriasis is a common, chronic disease condition for which there is no cure. The pathogenesis of psoriasis involves hyperproliferation of T cells as well as other variables such as cytokines, dendritic cells, tumour necrosis factor alpha (TNF-α). The clinical phenotypes of psoriasis include plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, and pustular psoriasis. Psoriasis is thought to be inherited, but can also be triggered by infections, drugs, vaccination, lifestyle, obesity. Topical therapies for mild to moderate psoriasis include emollients and keratolytic agents, corticosteroids, anthralin, vitamin D analogues, retinoids. Management of psoriasis must be individualized and may involve combinations of different medications and phototherapy.

Keywords: Psoriasis, T cells, Hyperproliferation, Anthralin, Phototherapy.