Abstract

EFFECT OF GRAPE SEED EXTRACT IN THEOPHYLLINE HYDROCHLORIDE AND IT’ S EVALUATION

Rasla Mol K.* and Surya Mohandas D.

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Abstract

Grape (Vitis vinifera) seed extract as a safer antioxidant found to have a great concentration of Flavonoids, Linoleic acid and Polyphenols. In the present study Controlled release matrix tablets of Theophylline Hydrochloride and Grape seed extract was prepared with HPMC, Chitosan and PVP as a single formulation by Wet granulation method with varying polymer ratios to investigate the stability changes of the formulation Matrix Tablet of Theophylline and Grape seed extract with that of marketed formulation of Theophylline. The granules are subjected for preformulation studies. Compressed tablets were evaluated for hardness, weight variation, friability, drug content, thickness and diameter. Formulations have showed compliance with pharmacopeial standards. IR spectroscopy revealed that there was no interaction between the drug, polymer and excipients. Among the formulations F-6 showed controlled 80.11 % after 8 hr. The kinetic treatment showed that the drug release followed Higuchi model. F-6 was subjected to Stability studies for 3 months period; it was found to be more stable when compared with that of marketed formulation of Theophylline. Drug release was found to be about 79.20 % in F-6 formulation which indicates a good stability of Theophylline matrix tablets with Grape seed extract as compared to marketed Theophylline drug release of only 70.15 % at the end of the storage period.

Keywords: Grape seed extract; Theophylline Hydrochloride; Controlled release; Matrix tablets; in vitro; Stability studies.