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Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

ANALYSIS OF THE ANTICANCER PROPERTIES OF BUFADIENOLIDE WITH EMPHASIS ON BREAST CANCER USING CHEMICAL-QUANTUM

Ana Karen Pérez-Pérez, Medardo Galdámez-Velázquez, Giovanny Flores-Romero, Samantha Suárez-Rodríguez, Alexis Torres-Solano and *Manuel González-Pérez

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Abstract

Bufadienolides (BDN) are a group of C-24 polyhydroxy steroids. Furthermore, BDN glycosidics contain a range of biological properties. These glycosides have cytotoxic, antitumor, and cardiotonic activities; however, the uncontrolled administration of BDN induces side effects. The objective was to characterize BDN and Amino Acids (AAs) by quantum chemistry to evaluate if BDN is an anticancer agent. HyperChem software was purchased as a quantum chemistry simulator. The fundamental basis of quantum calculations was the electron transfer coefficient (ETC) theory. We can see the ETC ordered according to the quantum well. It is observed that the BDN is in the middle part of the well. This location leads us to understand that BDN is a medium-acting substance. The information in the whisker and box plots shows the probability that it has an oxidative and an antioxidant interaction because pairs are found in the quantum well. We discovered that it has antioxidant and oxidizing properties at the same time.

Keywords: Anticancer Properties, Bufadienolide, Breast cancer, Chemical-Quantum.


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