Abstract

AMELIORATIVE EFFECT OF N-ACETYL-L-CYSTEINE ON SODIUM DICHROMATE-INDUCED ALTERATIONS OF HAEMATOBIOCHEMICAL PARAMETERS IN RATS

S. B. Mada*, M. M. Abarshi and O. E. Gabriel

Abstract

Protective effect of antioxidant N-acetyl-L-cysteine (NAC) on sodium dichromate induced-haemato-biochemical alterations was study. Rats were divided into four treatment groups of ten rats each. Group 1 received DMSO (2 mL/ kg) and served as normal control. Group 2 were administered with sodium dichromate (10 mg/kg) in 0.2 mL deionized water and served as negative control. Group 3 and 4 were administered with sodium dichromate (10 mg/kg) in 0.2 mL deionized water each and NAC (25 and 50 mg/kg) in 0.2 mL DMSO respectively. The treatment was carried out daily for 12 weeks. Results revealed NAC administration significantly (P < 0.05) reversed the hepatic damage in a dose-dependent manner when compared to nontreated group. Interestingly, our results showed administration of NAC significantly (P < 0.05) increase SOD and CAT activities along with elevation of GSH and decrease MDA levels in dose-dependent manner when compared to non-treated group. Moreover, NAC administration reversed the increase in urea and creatinine levels and restored haematological parameters when compared to non-treated group. The present study, suggests that NAC possess protective effect against sodium dichromate induced-alterations of haematobiochemical parameters in rats.

Keywords: Sodium dichromate; N-acetyl-L-cysteine; oxidative damage; haematological parameter