Abstract

ADVANCEMENTS IN SUSTAINED RELEASE DRUG DELIVERY SYSTEMS: DESIGN PRINCIPLES, FORMULATION STRATEGIES AND NOVEL APPROACHES

Kunwar Abdul Kalam* and Suneel Kumar Niranjan

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Abstract

Sustained release drug delivery systems have emerged as a promising approach to improve therapeutic effectiveness and patient compliance. This review article aims to provide a comprehensive overview of the advancements in sustained release drug delivery systems, focusing on design principles, formulation strategies, and novel approaches. The introduction highlights the background and significance of sustained release drug delivery systems in optimizing therapy for chronic conditions. The objectives of the review article include exploring the factors influencing system design, considering patient-specific considerations and personalized therapy, understanding the duration of therapy and sustained release requirements, and discussing the role of drug characteristics in selecting appropriate delivery systems. The review delves into the design principles of sustained release drug delivery systems, emphasizing patient-specific considerations and personalized therapy in system design. It discusses the duration of therapy and sustained release requirements, as well as the role of drug characteristics in selecting appropriate delivery systems. Formulation strategies for sustained release are explored, with a focus on matrix-based formulations, the role of polymers in controlling drug release kinetics, the use of excipients and additives for improved sustained release profiles, and novel approaches and technologies in formulation design. The advantages and challenges of matrix-based formulations are discussed, along with the role of polymers in achieving controlled release profiles. Excipients and additives are explored for their role in enhancing sustained release profiles, and novel approaches such as nanotechnology and 3D printing are highlighted for their potential in personalized medicine. In conclusion, this review article provides a comprehensive overview of the advancements in sustained release drug delivery systems. By considering design principles, formulation strategies, and novel approaches, researchers and practitioners can enhance therapeutic effectiveness, improve patient compliance, and shape the future of sustained release drug delivery.

Keywords: Sustained release drug delivery systems; Design principles; Formulation strategies; Polymers; Novel approaches.