WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

A REVIEW ARTICLE ON ADVANCED TRANSDERMAL DRUG DELIVERY SYSTEM

*Aarya Abhijit Tanawade, Yuvraj L. Pandhare, Lakhansingh A. Thakur, Amisha Salaskar, Harshad Pawar and Shruti Pawar

.

Abstract

In response to this new idea several transdermal drug delivery (TDD) systems have recently been developed, aiming to achieve the objective of systemic medication through topical application to the intact skin surface. They were exemplified first with the development of a scopolamine-releasing TDD system (Transderm-Scop) for 72 hr prophylaxis or treatment of motion-induced nausea, then by the successful marketing of nitroglycerin-releasing TDD systems (Deponit, Nitrodisc, Nitro-Dur, Transderm-Nitro and others) and an isosorbide dinitrate-releasing TDD system (Frandol tape) for once-aday medication of angina pectoris, as well as a clonidine-releasing TDD system (Catapres-TTS) for the weekly therapy of hypertension and of an estradiol-releasing TDD system (Estraderm) for the twice-a -week treatment of postmenopausal syndromes. Most recently another fentanyl-releasing TDD system (Duragesic) received FDA approval for the twice-aweek analgesic in cancer patients. Continuous intravenous infusion at a programmed rate has been recognized as a superior mode of drug delivery not only to bypass the hepatic first-pass elimination but also to maintain a constant, prolonged, and therapeutically-effective drug level in the body. A closely monitored intravenous infusion can provide both the advantages of direct entry of drug into the systemic circulation and control of circulating drug levels. However, such a mode of drug delivery entails certain risks and therefore necessitates hospitalization of patients and close medical supervision of the medication. Recently there has been an increasing awareness that the benefits of intravenous drug infusion can be closely duplicated, without its potential hazards, by continuous transdermal drug administration through intact skin.

Keywords: transdermal, drug delivery, velocity based device, ultrasound, thermal ablation, mechanical and electrical approaches, microneedle.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More