Abstract

SOLID LIPID NANOPARTICLES AS NOVEL DRUG DELIVERY SYSTEM: AN OVERVIEW

Abhish Bhagwan Jadhav* and A.D savkare

Abstract

Solid lipid nanoparticles are at the vanguard of the rapidly growing field of nanotechnology with numerous prospective applications in drug delivery, clinical research, Biotechnology, Cosmetology and in addition to other diverse sciences. Solid lipid nanoparticle offers great advantages over a traditional drug delivery system. A solid lipid nanoparticle (SLN) is a typically colloidal spherical with an average diameter between 10 to 1000 nm. Solid lipid nanoparticles hold a solid lipid core matrix that can solubilize lipophilic molecules as well as hydrophilic drugs. The lipid core of SLNs is stabilized by the surfactants (emulsifiers). Due to their inimitable size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The potential to incorporate drugs into nanocarriers offers a new archetype in drug delivery that could hold an immense promise in accomplishing the bioavailability enhancement accompanied by controlled and site specific drug delivery. Solid lipid nanoparticles offers enhance bioavailability by improving drug dissolution and permeability across intestinal cell wall by incorporation of drug in solid lipid nanoparticle .This review presents a discussion on the introduction, advantages, disadvantages, Nano structured lipid carrier, lipid drug conjugate, production procedures, Principle of drug release from SLN, pharmaceutical applications, characterization studies, and evaluation of SLNs.

Keywords: Solid lipid nanoparticles, NLC, LDC, nanocarriers, production techniques.