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Abstract

AN OVERVIEW ON VERSATILE PHARMACOPHORE OF PHTHALIMIDE DERIVATIVES

Sathish Annadurai*, Dr. S. K. Senthilkumar, Sanjay Babu, Sandhiya Uralliappan, Santhanam Sambath, Sethupathi Rajamani and Shahithabanu Ameer

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Abstract

Currently, phthalimide derivatives widely employed in therapeutic perpose owning to have very potent due to their antimicrobial, antiangiogenic, anticonvulsant, anxiolytics, Antioxidant, Tyrosinase inhibition, cytotoxic and toxicological effect, anti-inflammatory, anti proliferative, and HIV-I RT inhibitor activity. This review article is intended to provide highly relevant information on the biological activities of these compounds and their mechanisms of systemic action that have already been elucidated. The phthalimides and their derivatives studied in this study presented individual molecules, but also conjugated with other pharmacophoric groups, in order to improve their pharmacokinetic and pharmacodynamic aspects and thus generate better therapeutic response. The established documentation having the information about phthalimide moities with a powerful therapeutic profile which is used design & develop potential molecules and provide interest and opportunities for researchers work on phthalimide scaffold.

Keywords: Phthalimide derivatitves, phthalic anhydride, phthalic acid, imide.


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