Abstract

FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF HYDROXYPROPYL METHYLCELLULOSE AND POLYETHYLENE OXIDE USING PRAZOSIN HYDROCHLORIDE AS A MODEL DRUG

Chandan Singh Ahirwar*, Arshita Dhurve, Shefali Usrethe and Satendra Raidas

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Abstract

The goal of the current work was to develop and assess in vitro floating tablets of polyvinyl pyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC) using prazosin hydrochloride as a model medication. The effervescent method, which used sodium bicarbonate as a gas generator, was the basis for the floating pills. The dry granulation process was used to create the tablets. The impact of HPMC's viscosity grades and polymer concentrations on the medication release profile was assessed. Investigations were also conducted on how sodium bicarbonate and stearic acid affected the drug release profile and floating characteristics. The outcome of an in vitro dissolution investigation showed that raising the concentration of HPMC PVP and MCC may sustain the drug release profile. Combining sodium bicarbonate and stearic acid had no discernible impact on the medication release profile. The formulations using 20 mg of sodium bicarbonate per tablet demonstrated the expected buoyancy, with a floating lag time of around 2 minutes and a total floating time of more than 24 hours. The current work demonstrates that prolonged-release floating tablets of prazosin hydrochloride can be created using polymers such as HPMC, PVP, and MCC in combination with sodium bicarbonate as a gas-producing agent.

Keywords: Floating drug delivery system; HPMC; PVP; gastroretentive drug delivery system; prazosin; hydrochloride.