Abstract

TOPICAL GEL FORMULATION DEVELOPMENT, CHARACTERIZATION AND ANTI-ACNE ACTIVITY OF SWIETENIA MAHOGANY

Madhukar V. Shende*, Vivek Kahale and Nilesh Nalawade

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Abstract

Inflammatory acne vulgaris can be treated with systemic and topical antimicrobials, but their widespread use is linked to the emergence of resistant pathogens, raising concerns about microorganism resistance and highlighting the need for alternative non-antimicrobial agents. Anti-acne solutions using numerous extracts of common Indian plants are now being developed by a number of global corporations. The purpose of this research is to create a herbal gel formulation for the treatment of acne that includes Swietenia mahogany extract (in aqueous, methanol, ethyl acetate, and petroleum ether). Physical examination, washability, skin irritation testing, spreadability, pH, viscosity, extrudability, swelling index, and accelerated stability tests were all performed on the formulations in accordance with industry standards. Batch F2 was judged to be the most optimal of all the formulas tested. The yield from extraction was calculated to be 14.66 percent. While the MIC value of the aqueous S. mahogany extract was rather high for both Escherichia coli and Bacillus subtilis, the MIC value of the methanol and ethyl acetate extracts was moderate. While the S. mahogany petroleum ether extract shown the strongest anti-bacterial activity, it was not as potent as the gold standard medicine Clindamycin. The findings of the formulations (F1-F4) were similar to those of the extracts, and they exhibited less activity than the commercially available herbal product.

Keywords: Swietenia mahogany, Acne, Formulation, Characterization, Antimicrobial, Extract.