Abstract

THERAPEUTIC EFFICACY OF BONE MARROW ASPIRATE AND PLATELET ENRICHED PLASMA (AUTOLOGOUS) STUDIED IN OSTEOARTHRITIC PATIENTS - PROOF OF CONCEPT STUDY

Venkatesh Movva, Vijayalakshmi Venkatesan*, Syed Khaleel, Sunitha Manne Mudhu, Swetha Birineni and Balakrishna Nagalla

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Abstract

Objective: The present study explores the beneficial effects of combining Bone Marrow Aspirate Concentrate (BMAC) and platelet- Rich Plasma (PRP) as a therapeutic strategy for pain and functional management of Knee Osteoarthritic (KOA) patients. Methods: For this study, ten patients were recruited and line of assessment included by both symptomatic and radiography. Treatment strategy included ,aspiration of bone marrow from the iliac crests under local anesthesia, preparation of BMAC and PRP under sterile conditions (three step differential centrifugation) followed by BMAC and PRP administration to the arthritic (bilateral) knees, guided by image intraarticular injections (IAR) using ultrasound and X-ray (fluoroscope). Pain and functionality scores were determined at baseline /0 followed up by post-injection periods of 1, 4, 6, 12 months. Validated questioners include, Numeric pain rating scale (NPRS), knee injury and osteoarthritis outcome score (KOOS) and knee-related quality of life and Short Assessment of patient satisfaction (SAPS). Results: Using functional analysis like NPRS, KOOS and SAPS subscale, we show positive clinical outcomes in post injected patients (0, 1, 4, 6, 12) as compared to baseline data. Also, no adverse effects were reported from patients during the study. Conclusions: We advocate the beneficial outcomes of combing BMAC and PRP to treat KOA.

Keywords: Knee osteoarthritis, Bone marrow aspirate concentrate Platelet-rich plasma.