Abstract

ORGANOGEL: A NOVEL APPROCH FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Prakash T. Sangale* and Gadhave Manoj V.

Abstract

A gel may be defined as a semi-solid formulation having an external solvent phase, a polar (organogel) or polar (hydrogel) immobilized within the spaces available of a three dimensional networked structure. Organogel, a viscoelastic system, can be regarded as a semi-solid preparation. An organogel is a non-crystalline, non-glassy thermo reversible (thermoplastic) solid material composed of a liquid organic phase.The three-dimensional networked structure formed due to the physical interactions amongst the self assembled structures of compounds regarded as gelators. It is a potential carrier for transdermal drug delivery system. If the liquid phase is apolar in nature then gels may be called as organogel otherwise called as hydrogel. Organogel can be prepared by solid matrix and fluid filled matrix method. The chemical enhancer used in dermal formulation for permeation of drug through the skin, it may be harmful, produce irritation as in chronic application. Organogel does not require use of chemical enhancer for facilitate drug through the skin. Lecithin, gelatin or Sorbitan ester base use for gellating agent. In general, organogels are thermodynamically stable in nature and have been explored as matrices for the delivery of bioactive agents. This article gives information about Properties of organogels, types of organogel. Types of organogelator, properties and evaluation parameter of organogel with application.

Keywords: Topical Delivery System, Organogel, Fluid-filled fiber mechanism, Organogelator.