Abstract

VARIOUS THERAPEUTIC APPROACHES FOR ORAL LICHEN PLANUS: A COMPARATIVE EVALUATION

*Dr. Sadhana J. Kothiya, Dr. Shilpa J. Parikh and Dr. Jigna S. Shah

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Abstract

Introduction: Oral Lichen Planus (OLP) is a chronic disease that affects oral mucosa as well as the skin. Many therapeutic modalities have been tried for management of OLP. Amlexanox is a topical immunomodulator, anti-allergic drug, the strong anti-inflammatory action of which, make it a very strong treatment option for OLP. Aim and Objectives: The aim and objectives of the present study were to evaluate and compare the efficacy of topical application of 5% Amlexanox, 0.1% Triamcinolone Acetonide and 0.025% Fluocinolone acetonide oral paste in the treatment of Oral Lichen Planus. Materials and Methods: In the present study, 55 patients clinically diagnosed with OLP were randomly divided into three groups for topical treatment– group I (5% Amlexanox, n=19), group II (0.1% Triamcinolone acetonide, n=18) and group III (0.025% Fluocinolone acetonide, n=18). Assessment of the appearance score and VAS score was done at baseline, 1st week,2nd week,4th week,6th week, and 3rd month. The data were analyzed by SPSS 23 software, using the Chi-square test, Kruskal-Wallis test, and Post hoc Dunn test. Result: Patients in all three groups were asymptomatic at the end of the treatment course. VAS score reduction was more in topical 5% Amlexanox therapy than 0.1% Triamcinolone acetonide and Fluocinolone acetonide therapy, while reduction in appearance score was earliest in 0.1 % Triamcinolone acetonide therapy. Conclusion: Amlexanox can be used effectively as a treatment modality for OLP, without any adverse effects compared to corticosteroids.

Keywords: Oral Lichen Planus, Amlexanox, Triamcinolone acetonide, Fluocinolone acetonide.