WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

CHIRAL SWITCH-NEW EXPRESSWAY TO STRATEGIC DEVELOPMENT IN API INDUSTRY

Vikrant Dandekar*, Sathe Milind, Vijay Tawari and Amrit Karmarkar

.

Abstract

The chirality of drugs has emerged as a major area in API Pharmaceutical Industry. Single enantiomers offer some advantages primarily related to three-dimensional structure and arrangement of atoms in molecule. Enantiomeric purity is achieved either by the switch from an existing racemic drug to the single enantiomer or by the synthetic development of an enantiomerically pure chiral drug. The potential advantages of chiral switch can be related to a higher therapeutic index due to better potency, selectivity and fewer adverse effects, faster onset of action and exposure of the patient to lower drug dosages. Therefore, it is important to promote the chiral separation and analysis of racemic drugs in pharmaceutical industry as well as in clinic in order to eliminate the unwanted isomer and to find an optimal treatment and a right therapeutic control for the patient.

Keywords: Chiral Switch, single enantiomer, Active Pharmaceutical Industry (API), racemic mixture, Chiral separation, Chiral resolution.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More