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Abstract

EFFECT OF COSMETIC AMPOULE ON PORE REFINEMENT AND SKIN BOOSTING

Yoshida Hiroki MD*

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Abstract

The most critical function of the skin is to protect the human body from external physical and chemical factors. Sebaceous glands present in the skin play a significant role in this protection by secreting sebum, which is expelled through pores onto the skin surface. This excreted sebum helps prevent moisture evaporation from the skin's surface and plays a crucial role in protecting the body from bacteria.[1] The skin is divided into three layers: epidermis, dermis, and subcutaneous fat layer. The basal layer (keratinocytes) resides at the bottom of the epidermis, continuously undergoing cell differentiation. The differentiated cells move upward through the stratum spinosum and stratum granulosum, eventually forming the outermost layer called the stratum corneum, which is shed every 28 days. Disruptions in this cycle can lead to a thickened stratum corneum and roughened skin texture. Additionally, accumulation of keratin around pores can block the exit of sebum, leading to the development of whiteheads, blackheads, and acne, which can become inflamed due to bacterial infection.[2,3] This repetitive cycle can widen pores by affecting the surrounding dermal layer. Various factors influence sebum production, such as diet, hormones, age, gender, and regional differences on the skin.[4] Among these, hormones play a significant role, with androgens (male hormones) having a particularly influential role in the development, synthesis, and size of sebaceous glands. Androgen receptors present in the sebaceous glands respond to hormones locally within the cell nucleus, similar to the way androgens act on the prostate.[5] This study aims to investigate the efficacy of a skin booster, MTPA (Monteranc Teracle Pore Ampoule), in reducing pore size and improving skin-boosting capabilities to address common skin concerns related to large pores and excessive sebum production.

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