Abstract

TAXOL PRODUCTION USING MICROBES: A REVIEW

Harshitha V., Krithika K., Mohan P., Zeeba Naaz S., S. Narendra Kumar*, Dr. Ajeet Kumar Srivastava and Dr. Lingayya Hiremath

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Abstract

Taxol is a powerful, effective and often-used anticancer drug, also called paclitaxel. Since the first paclitaxel-producing fungi were described more than 15 years ago, microorganisms have been researched as potential substitutes for an ethical, straightforward, and affordable method of taxol production. Nevertheless, despite extensive studies on paclitaxel-producing bacteria, no commercial fermentation method has yet been applied. This study aims to review the microbes involved in taxol production to date and the present status of ongoing efforts to produce and analyze the process of microbial fermentation for paclitaxel production.

Keywords: Taxol, Taxomyces, Paclitaxel, Anti-cancer, Microbial biotechnology, Biosynthetic pathway.