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Abstract

FORMULATION AND EVALUATION OF VILDAGLIPTIN – MORINGA OLEIFERA MICROBEADS

Krishnaveni Manubolu*, Sreenivasulu Munna, Lakshmi Priyanka K., K. Lavanya, S. Chandana, Prashanth

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Abstract

Background: Natural gums and mucilages are being used due to their abundance in nature, safety and economy. The present investigation was an effort to study the suitability of gum obtained from Moringa oleifera as polymer in sustained release microspheres combination with another natural polymer sodium alginate. Gum is obtained from exudes of stem of Moringa oleifera. The gum is a polyuronide constituting of arabinose, galactose, and glucoronic acid in the ratio of 10:7:2, and rhamnose in traces. In this study gum isolated from trunk of Moringa oleifera was studied at different concentrations and conditions alone as well as in combination with sodium alginate. Aim of the study: To prepare and evaluate vildagliptin microbeads using moringa oleifera polymer which is a natural polymer. Methods: The microparticles containing vildagliptin was prepared by ionotropic gelation method. Results: Various parameters like colour, odour, taste, solubility, sphere forming capacity and its stability were studied. The gum was found to be hygroscopic and organoleptically acceptable. The stability of spheres formed by Moringa gum alone and in combination with sodium alginate in different crosslinking agents was observed. The gum was found to form a spherical bead at 7% concentration. The stability of the microspheres formed from moringa gum was increased with the addition of sodium alginate in different concentrations. By increasing the concentration of sodium alginate with 7% moringa gum affected the size and shape of spheres. From the study it was concluded that Moringa gum and sodium alginate are biocompatible and can be effectively used as polymer in sustained release microspheres. Conclusion: after thorough study of the results obtained it was concluded that moringa oleifera can be used as carrier for preparation of microbeads. There is a siginificant difference between the formulations prepared using moringa oleifera in different proportions when it was treated using ANOVA statistical analysis. The drug release was varying form formulations to formulations it is due the particle size variation F4 exhibits 750μm which attributed to 12 hrs drug release and it exhibited 53.5 times swelling for optimum drug release. So, F4 is observed to exhibit optimized sustained effect.

Keywords: Vildagliptin, moringa oleifera, natural polymer, controlled drug release.


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